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Worksheet: Mass Spectrometry Methods


Why is inductively coupled plasma (ICP) typically only used as an ionization method for elemental analysis?

  • AIt requires the sample to be dissolved in a carrier gas prior to sample injection.
  • BOnly low molecular weight molecules can be analyzed.
  • CICP produces an unpredictable fragmentation pattern.
  • DAll structural information is lost due to extremely high plasma temperatures.


What are fast atom bombardment (FAB) and secondary ion mass spectrometry (SIMS) useful techniques for?

  • AProtein sequencing
  • BTrace metal analysis
  • CHalide analysis
  • DDepth profiling


What are MALDI and ESI?

  • ASeparation methods used prior to MS analysis
  • BDetection methods used for spectral fingerprinting
  • CMass analysis techniques requiring external calibration
  • DIonization methods commonly used for biochemical analysis


What is the negative mode of chemical ionization best suited for analysis of?

  • AAmines
  • BCarbocations
  • CAromatics
  • DHalides


Which MS ionization technique is most useful for component analysis of metal-containing compounds, leaving fragments intact?

  • AMatrix assisted laser desorption ionization (MALDI)
  • BInductively coupled plasma (ICP)
  • CElectrospray ionization (ESI)
  • DElectron impact (EI)