Worksheet: Monoclonal Antibodies

In this worksheet, we will practice recalling the main steps in producing monoclonal antibodies, and describing some medical applications of monoclonal antibodies.

Q1:

In which of the following are monoclonal antibodies not used?

  • ADisease treatment
  • BPregnancy tests
  • CDisease diagnosis
  • DDNA paternity tests
  • EDrug delivery

Q2:

Why are cancer cells used in the production of monoclonal antibodies?

  • ABecause cancer cells produce antibodies in an immune response
  • BBecause cancer cells divide easily and rapidly
  • CBecause cancer cells induce the production of antibodies by the immune system
  • DBecause cancer cells can be stimulated to differentiate into any type of specialized cell

Q3:

Which of the following best describes monoclonal antibodies?

  • AThey are antibodies produced from clones of a range of lymphocytes.
  • BThey are antibodies produced from different versions of a single lymphocyte.
  • CThey are antibodies produced from clones of a single lymphocyte.
  • DThey are antibodies produced from clones of a single organism.

Q4:

Complete the following definition: Antibodies are proteins produced by that respond to and target antigens.

  • Aerythrocytes, all types of
  • Blymphocytes, all types of
  • Cerythrocytes, specific
  • Dlymphocytes, specific

Q5:

Which of the following best describes a hybridoma cell?

  • AA lymphocyte fused with an antibody
  • BA cancer cell fused with an erythrocyte
  • CA cancer cell fused with an antibody
  • DA lymphocyte fused with a white blood cell
  • EA cancer cell fused with a lymphocyte

Q6:

Which of the following is true about antibodies and antigens?

  • AAntibodies will bind to different antigens on the same pathogen.
  • BAntibodies will bind to a range of antigens all of which have identical shapes to them.
  • CAntibodies will bind to specific antigens to which they have a complementary shape.
  • DAntibodies will bind to the specific antigens that are shaped identically to them.

Q7:

What molecules on the surface of a pathogen initiate an immune response in humans?

  • ALymphocytes
  • BAntibodies
  • CHybridomas
  • DAntigens

Q8:

Monoclonal antibodies that recognize and bind to cancer cells can be produced.

Diagram A shows an antibody attached to a radioactive marker. Diagram B shows an antibody attached to a drug.

Which antibody could be used to locate cancer cells in the body?

  • AA
  • BB

Which antibody could be used to deliver drugs that target cancer cells within the body?

  • AB
  • BA

Q9:

The diagrams provided briefly outline how monoclonal antibodies can be used in pregnancy tests.

The person taking the test will urinate at the bottom of the test strip; the fluid will move down, and specific hormones in the urine will be detected.

The hormone hCG is primarily produced in pregnant women.

What is the main reason that hCG will bind to the antibodies?

  • AThe antibodies and the hormone have the same shape.
  • BThe hormone has hydrogen bonds that bind to the antibodies.
  • CThe antibodies and the hormone bind by electrostatic attraction.
  • DThe hormone has a complementary shape to that of the antibodies.

What would you expect to see in the result line if the pregnancy test was positive?

  • AA colored line
  • BNothing

What would you expect to see in the result line if the pregnancy test was negative?

  • ANothing
  • BA colored line

Q10:

The diagram provided shows a part of the process used to make monoclonal antibodies.

What type of cell is cell A?

  • ACancer cell
  • BLymphocyte
  • CErythrocyte
  • DHybridoma

What type of cell is cell B?

  • AErythrocyte
  • BHybridoma
  • CLymphocyte
  • DCancer cell

What type of cell is cell C?

  • ALymphocyte
  • BHybridoma
  • CCancer cell
  • DErythrocyte

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