Worksheet: NMR Sample Preparation

In this worksheet, we will practice describing sample preparation for NMR spectroscopy, including selection of solvent, filtration, and concentration.


Which of the following would be a poor choice as a proton NMR solvent?

  • ADeuterium oxide
  • BAcetone-D6
  • CCarbon tetrachloride
  • D o-toluene


Which of the following is NOT a reason why tetramethylsilane (TMS) is often used for a reference in NMR spectroscopy?

  • AIt gives a single, sharp peak in a region where other organic molecules do not have signals.
  • BIt is chemically inert and miscible with organic solvents.
  • CIt is easily removed from the sample after analysis.
  • DIts signal appears at the same frequency regardless of the applied magnetic field.


Magnetic Resonance Imaging (MRI) is an application of NMR spectroscopy in which of the following ways?

  • AIt scans for unique nuclei within human tissues.
  • BIt measures the distribution of carbon nuclei in the body.
  • CIt allows a non-invasive measure of bone density.
  • DIt measures the distribution of hydrogen nuclei in the body.

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