Worksheet: COSY NMR Spectra

In this worksheet, we will practice using 2D correlation spectra to determine which protons in a compound show significant spin–spin coupling.


Fill in the blank: In a COSY spectrum, the dark spots along the diagonal .

  • Aallow distinctions to be made between heteronuclear coupling constants
  • Bgive the most structural information because they differentiate between different hybridizations
  • Cdo not yield structural information because they correspond to the same peak on each coordinate axis
  • Ddo not give any structural identification because they are too intense to be deconvoluted

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