Video Transcript
In this video, we will be
discussing how nuclear radiation can be used in medicine. And when we say medicine, we don’t
just mean the tablets that people ingest. What we’re talking about is
medicine, the subject. The study of how to treat people
and their illnesses. Now, nuclear radiation can have
positive uses, both in diagnosing certain illnesses and also in treating them. Here, we will look at three uses
for nuclear radiation in medicine: radioactive tracers, gamma-ray beam therapy, and
radioactive implants. So let’s start by looking at
radioactive tracers.
A tracer is a radioactive substance
that’s either injected into the bloodstream of a patient or ingested by the patient
in some form of food or drink. That then ends up tracing the flow
of either blood or some other substance, such as water, throughout the body. Because, remember, the tracer is
radioactive. And this means that as the tracer
moves throughout the body, it emits radiation, which can be detected outside the
body. And this is done by detectors
placed outside the body. In other words, as the tracer moves
around in the body, the radiation detectors on the outside can detect where the
tracer actually is.
And because the tracer is flowed
with either blood or water or some other substance in the body, the reading on the
detectors will help us to find out exactly where in the body the blood or the water
or whatever substance we’re following is flowing correctly and where exactly there’s
something going wrong. For example, if there’s a blockage
of some sort in the bloodstream and a lot of blood is collecting in this region of
our patient, then a large amount of the radioactive tracer will collect there,
therefore emitting lots of radiation from that point. And the detectors will be able to
pick this up. So we can figure out exactly where
there’s a blockage in the body or where the substance that’s flowing is not flowing
properly.
Now, an important point to be made
here is that the radiation emitted by the radioactive tracer must be able to be
detected outside the body. And because the tracer itself is
inside the body, the type of radiation that the tracer must emit should have a high
penetrating power, which basically is the ability of the radiation to penetrate
through a material. And in this case, the material that
the radiation needs to penetrate through is the human body.
Now, let’s recall that out of the
three most commonly discussed types of ionizing radiation — so that’s alpha
radiation, beta radiation, and gamma radiation — the one which has the highest
penetrating power is gamma radiation. It’s the one that can travel the
furthest through materials, which means that is the most likely type of radiation
that will be able to get out of the body when emitted by the radioactive tracer. And an added benefit of using gamma
radiation for radioactive tracers is that out of these three types of ionizing
radiation, gamma is the most weakly ionizing, which means that it’s the least likely
of the three types of radiation to interact with cells in the body and end up
damaging them. Because if we used alpha or beta
radiation, then they would cause a lot of damage to the cells inside the body and
often would not even escape the body. So detecting alpha and beta outside
the body would be difficult. And on top of that, they would
cause a lot of damage to cells in the body. So we’re best-off using gamma
radiation.
Now, another point to be made is
that a radioactive substance will have some half-life, where half-life is defined as
the amount of time taken for half of the radioactive substance to decay. Now, the half-life of the
radioactive substance that we use as a tracer needs to be appropriate. So what do we mean by this? Well, firstly, the half-life of the
substance that we use as a radioactive tracer should not be too long. Because when we inject a
radioactive tracer into the human body or ingest it for that matter, we want to be
able to detect the radiation coming from it for a period of maybe a few minutes or
at most a few hours, because that’s how long it’ll take the doctors to set up the
detectors and scan the patient and also allow enough time for the tracer to flow
through the body normally. But if the half-life is too long,
then the tracer which will actually remain inside the body after the doctors have
finished all their scans will still continue to emit radiation. And so, our patient will remain
radioactive for a very long period of time. And that could be days or months or
even years, depending on the half-life of the substance that we used as a
radioactive tracer.
In other words, our radioactive
tracer substance must have a half-life of, at most, a few hours. But then, the half-life can’t be
too short, either. If the half-life is on the order of
a few seconds, then all of the radioactive substance which is being injected into
the body will decay away very quickly, sometimes even quicker than the time taken
for the substance to flow around the body. And so from this, we can gather
that the half-life of the substance that we use as a radioactive tracer must be at
least a few minutes. But ideally, it’ll be a few hours
and realistically should not be more than a few hours. And so, that’s where we can deduce
about radioactive tracers.
Now, notice that radioactive
tracers are used for diagnostic purposes because we send a radioactive substance
around the body in order to diagnose any problems that a patient might have, for
example, a blockage. The tracer itself is not used to
treat any problems that the patient might have. So let’s take a look at another use
of nuclear radiation in medicine that is used for treatment as a post-diagnosis.
This second use of nuclear
radiation and medicine is known as gamma-ray beam therapy. Now, to understand this use of
radiation, let’s first imagine that we’ve got a patient here that has a cancerous
tumor somewhere in their body. Let’s say they’ve got a cancerous
tumor here, somewhere in their stomach. Well, gamma-ray beam therapy is
used to treat a tumor like this. And of course, as the name
suggests, we use a radioactive isotope that emits gamma rays. Specifically, the isotope is placed
inside a machine, such that when the radioactive isotope emits gamma rays, the
machine only allows a narrow beam of gamma rays to pass out of the machine. And the beam itself can be very
accurately directed towards the tumor.
Now this is important because we
want to reduce the exposure of the rest of the patient’s body to any radiation
because at the end of the day, radiation is going to kill living cells. And so, we want to direct it so
that it maximally kills tumor cells, cancer cells, whilst minimizing the damage to
the rest of the human body. In fact, if we zoom in a little bit
to where the patient’s tumor is, and we imagine that the tumor is somewhere inside
the patient’s body rather than on the surface on their skin, then a rather clever
thing that can be done is to use multiple gamma-ray beam therapy machines to direct
multiple beams of gamma rays at the tumor. And the reason that this is done is
because then each beam of gamma rays can be weakened massively so that as they pass
through the body, each beam of gamma rays causes minimal damage to the healthy cells
of the body. But because all of the gamma ray
beams are targeted at the tumor, they cause maximum damage within the tumor itself
and hopefully end up shrinking and destroying the tumor, thus effectively treating
the cancer in the patient.
So now that we’ve learned what
gamma-ray beam therapy is, let’s once again very quickly discuss the half-life of
the substance that’s used to generate these gamma rays. Let’s imagine that inside our
machine, we’ve got a lump of substance that generates gamma rays. Now, this lump of substance must
have an appropriate half-life because if the half-life is too short, then it takes
very little time for most of the substance to decay. And if most of the substance decays
very quickly, then lots of gamma rays are released in a very short period of
time. This means that the machine would
have to absorb most of them. And only a few would be able to be
emitted as part of the gamma ray beam. And so, this is highly
wasteful. Plus, the sample won’t last very
long. And we’ll have to replace it very,
very quickly because most of it is decayed away in a short period of time.
Conversely, the half-life of our
substance cannot be very long because if it is, then only a few particles in that
substance would decay per unit time. And so, only very few gamma rays
will be released per unit time, which means we might not be able to get a strong
enough beam to emanate from the machine. And hence, there’s a balancing act
here as well. The half-life must be just
right. It cannot be too long or too
short. Anyway, let’s move on to looking at
another use for radioactive substances in treating illness. We will be looking at radioactive
implants.
Let’s imagine once again that we’ve
got a patient who has a tumor somewhere in their stomach. Well, a doctor can choose to place
radioactive implants very close to this tumor, sometimes even inside the tumor,
where the radioactive implants are represented by these small blue dots. Because these implants, obviously
made up of some radioactive substance, are usually quite small, shaped like seeds or
little rods. Now, these implants are placed in
the body for an extended period of time, maybe something like a few days or a few
weeks even. And because they’re placed very
close to a tumor or even inside the tumor, what they do is that they emit radiation
over an extended period of time, a few days or a few weeks and are hence attacking
the tumor over a long time. This means that the implants can
release small amounts of radiation constantly for a few days or weeks. And that is how the tumor can be
treated.
As opposed to gamma-ray beam
therapy, where lots of radiation is sent towards the tumor in a short period of
time, radioactive implants emit small amounts of radiation over an extended period
of time. Now, because radioactive implants
are placed very close to the tumor itself, the type of radiation they emit doesn’t
need to be massively penetrating because we don’t need it to come out of the body
or, for that matter, to go very far into the body, away from where the implants
are. So if we think back once again to
the three most commonly discussed types of ionizing radiation, alpha, beta, and
gamma, we can recall that out of the three, gamma has the largest penetrating power,
as we’ve seen earlier, and alpha has the lowest penetrating power. Conversely, gamma has the weakest
ionizing power, and alpha has the strongest ionizing power.
Now, for this particular purpose
for radioactive implants, either beta-emitters or sometimes gamma-emitters are
used. But hang on! Didn’t we say that we wanted
something that wasn’t strongly penetrating and ideally was highly ionizing so that
it could kill the tumor quickly? And therefore, shouldn’t we be
using Alpha radiation? Well, we might think that makes
logical sense. But in reality, alpha radiation is
far too dangerous to have inside the body. Because if we were to implant out
alpha radiation in the body, then it would cause a lot, a lot of damage, not just to
the tumor around it, but possibly to healthy cells as well.
And then, there’s the matter of
actually implanting the implants into the body because they have to get there
somehow. The doctor has to put them
there. And in the process of putting them
there, for example, if they were to surgically place them inside, then in that
period of time the radioactive substance that was used as an implant would still be
emitting radiation. And so, all of this alpha radiation
would really, really damage healthy cells in the human body. And therefore, we do not place
alpha-emitters in the human body. That’s why in most cases we stick
with beta-emitters because beta radiation has a medium ionizing power and a medium
penetrating power. And in cases where the tumor is
small, we can sometimes use a gamma-emitter as well.
At which point, we can finally
discuss the half-life of the substances used as radioactive implants. Now, like we’ve mentioned already,
the implants need to be emitting small amounts of radiation over a long period of
time, something like a few days or a few weeks. And hence, we need to use a
substance that has a half-life of a few days or a few weeks, once again, not too
short or not too long for the particular purpose that we need to use it for. And it’s an important point to
make: regardless of whatever purpose we want to use a radioactive isotope for, we
need to make sure we use the radioactive isotope that has an appropriate
half-life.
And with all of that being said,
we’ve now looked at three uses for nuclear radiation in medicine. So let’s now get some practice with
this by looking at an example question.
What type of radiation does a
radioactive isotope need to emit to be useful as a radioactive tracer? A) Gamma and beta radiation. B) Neutron radiation only. C) Beta radiation only. D) Alpha radiation only. E) Gamma radiation only.
Okay, so to answer this question,
let’s first recall what we mean by a radioactive tracer. Well, a radioactive tracer is a
radioactive substance that’s injected into the human body or ingested with some food
or drink that then flows around the body. For example, if it’s injected into
the body, then it flows with the blood. And because the substance is
radioactive, it gives off radiation as it moves through the body. Because of this, we can place a
detector outside the body that detects the radiation coming from inside the
body. And that allows us to see that the
flow of the substance that we’re testing — in this case, the blood — is normal
inside the body.
If something is wrong, however, for
example, if we say that there’s a blockage in the flow of the blood here in the body
of the patient, then when we place a detector in that region, we will find that lots
of radiation is coming from there as lots of blood piles up there and therefore lots
of radioactive tracer parts up there. And in other regions of the body,
for example, after the blockage, we might only get a few tracers of radiation. So that’s the purpose of a
radioactive tracer.
Now, importantly, the radiation
coming from the radioactive tracer needs to pass through the body so that it’s
detected outside the body. In other words, the type of
radiation that the tracer must emit must have a high penetrating power. It must be able to penetrate quite
deep into any material because remember, the radiation itself needs to penetrate
through a lot of flesh and skin in order to escape the body. Now, at this point, we can see that
four different kinds of radiation have been mentioned in the options given to us in
the question. We’ve seen alpha radiation, beta
radiation, gamma radiation, and neutron radiation, otherwise known as free
neutrons.
Well, we can recall that alpha
radiation has a very low penetrating power. It cannot penetrate very deep into
materials before it interacts with them and is absorbed by material. And on top of this, alpha radiation
is highly ionizing. But if we were to inject a
substance into the body that produces highly ionizing radiation, then the radiation
would very quickly cause a lot of damage inside the body. It would ionize a lot of the cells
in the body. And as well as this because alpha
radiation cannot penetrate very far, most of it would not be able to escape the
body. And so, our detectors would be
useless at that point. Therefore, we do not want anything
that emits alpha radiation.
And for a similar reason, we can
eliminate beta radiation as well. Because even though beta radiation
can penetrate further than alpha radiation and is not quite as strongly ionizing as
alpha radiation, it’s still not ideal because quite a lot of beta radiation would be
absorbed before it got out of the body. And beta radiation is still
strongly ionizing enough that it would cause a fair amount of damage in the
body. And so, we can eliminate anything
that produces beta radiation as well.
Now, when we think about free
neutrons, well different substances interact differently with a beam of free
neutrons. Nevertheless, neutrons are
generally known to have a high penetrating power. They can get quite far through a
material. So we might think that a
neutron-emitter is a useful isotope in this case. But actually, it turns out that
neutrons are quite hard to detect. So even if neutrons were to make
their way out of the body, detecting them would be quite difficult. And as well as this, some neutrons
would be absorbed by the body, which means that these neutrons would interact with
the atoms in the body.
This is problematic because
sometimes when neutrons interact with some material, they cause other forms of
radioactive decay. In other words, a neutron
interacting with the body could result in alpha or beta or gamma radiation being
emitted. And this is problematic because, as
we’ve already seen, we do not want any alpha or beta radiation within the body for
the purposes of simply diagnosing how well a particular substance is moving around
inside the body. And for these reasons, we do not
want neutron-emitters to be used as radioactive tracers.
And so, it looks like gamma
radiation is the best of all worlds. It’s highly penetrating, so we’re
likely to detect it outside the body, and also relatively weakly ionizing, so it
won’t cause a lot of damage. And hence, our answer is that a
radioactive isotope used as a radioactive tracer must emit gamma radiation only.
So now that we’ve looked at an
example question, let’s quickly summarize what we’ve talked about in this
lesson. We firstly learned about
radioactive tracers, which are gamma-emitting isotopes injected in the body of a
patient to study the flow of substances, for example, blood. And radioactive tracers are used
for diagnosis, in other words, to figure out if there’s some sort of problem with
the patient. Their purpose is not to treat
illness. Secondly, we saw that gamma-ray
beam therapy consists of beams of gamma rays directed into the body of a patient to
treat a cancerous tumor. And finally, we saw that
radioactive implants are beta- or gamma-emitters placed in the body near a tumor to
irradiate that tumor over a few days or weeks. We also saw that in each case, it
is important to choose an isotope with an appropriate half-life. And so, that has been an overview
on how nuclear radiation can be used in medicine.