Question Video: Applying Knowledge of Hybridization to DNA and RNA | Nagwa Question Video: Applying Knowledge of Hybridization to DNA and RNA | Nagwa

Question Video: Applying Knowledge of Hybridization to DNA and RNA Biology • Third Year of Secondary School

Is it possible to bind DNA and RNA by hybridization?

01:55

Video Transcript

Is it possible to bind DNA and RNA by hybridization? (A) Yes, it is possible since RNA and DNA can share complementary nucleotides. (B) No, it is impossible since RNA and DNA cannot share complementary nucleotides.

To answer this question we need to know what is meant by hybridization and by complementary nucleotides. Let’s start with complementary nucleotides. Here’s a segment of DNA. Let’s zoom in on this section. Here are two strands of DNA that together make up the double helix. Both RNA and DNA are polymers of nucleotides. Nucleotides are made up of three parts: a phosphate group, a pentose sugar, and a nitrogenous base. In DNA, there’s four nitrogenous bases: guanine, represented in orange; cytosine, represented in blue; adenine, represented in green; and thymine, represented in pink.

Cytosine can form three hydrogen bonds with guanine, as shown here. And adenine and thymine can form two hydrogen bonds. These bases are said to be complementary because they can hydrogen-bond with each other. These hydrogen bonds is what keeps the two strands of DNA together to form the double helix. Hybridization is the process of combining two complementary molecules of single-stranded DNA or RNA. This can form a double-stranded hybrid molecule.

RNA has most of the same bases as DNA except instead of thymine, it uses uracil, represented in red. These bases in RNA can still form the same hydrogen bonds with their complementary bases in DNA. Uracil forms two hydrogen bonds with adenine. So in terms of hybridization, the correct answer is (A). Yes, it is possible since RNA and DNA can share complementary nucleotides.

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